Biologic Agents in Rheumatology: A Virtual Reality Tour through Psoriatic Arthritis and Rheumatoid Arthritis
- Cantini F, et al. Second-line biologic therapy optimization in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Semin Arthritis Rheum. 2017;47(2):183-92.
- Cantini F, et al. Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis. Semin Arthritis Rheum. 2016;45(5):519-32.
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Psoriatic/Rheumatoid Arthritis Resources: Associations/Foundations
American Academy of Dermatology
American College of Rheumatology
Rheumatology Research Foundation
World Health Organization
Oculus Virtual Reality View: New Biologics for Improved Skin Clearance in Psoriasis
- Alamdari HS, et al. Psoriasis and cardiovascular screening rates in the United States. J Drugs Dermatol. 2013;12:e14-9.
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- Takeshita J, et al. Psoriasis and comorbid diseases: Implications for management. J Am Acad Dermatol. 2017;76(3):393-403.
Psoriasis Resources: Associations/Foundations
American Academy of Dermatology
American Dermatological Association
Centers for Disease Control and Prevention
National Psoriasis Foundation
World Health Organization
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Alamdari HS, Gustafson CJ, Davis SA, Huang W, Feldman SR. Psoriasis and cardiovascular screening rates in the United States.J Drugs Dermatol. 2013;12:e14-9.
Amatya B, Wennersten G, Nordlind K. Patients’ perspective of pruritus in chronic plaque psoriasis: A questionnaire-based study. J. Eur. Acad. Dermatol. Venereol. 2008;22:822–826.
Armstrong AW et al. Quality of life and work productivity impairment among psoriasis patients: findings from the National Psoriasis Foundation survey data 2003-2011. PLoS One. 2012;7:e52935.
Afif W, Loftus EV Jr, Faubion WA, et al. Clinical utility of measuring infliximab and human anti-chimeric antibody concentrations in patients with inflammatory bowel disease. Am J Gastroenterol. 2010;105:1133-9.
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Bissonnette R, Iversen L, Sofen, et al. Tofacitinib withdrawal and retreatment in moderate-to severe chronic plaque psoriasis: a randomized controlled trial. Br J Dermatol. 2015;172:1395-1406.
Blauvelt A, et al. Efficacy and Safety of Continuous Ixekizumab Treatment for 60 Weeks in Moderate-to-Severe Plaque Psoriasis: Results from the UNCOVER-3 Trial. American Academy of Dermatology Annual Meeting, Washington, DC; March 4-8, 2016. Late-Breaker Abstract #3855.
Blauvelt A, Ball S, et al. Safety profile of patients achieving complete or near complete resolution of moderate-to-severe psoriasis after 12 weeks of etanercept or ixekizumab: Integrated analyses from UNCOVER-2 and UNCOVER-3. Academy of Dermatology Annual Meeting, Washington, DC; March 4-8, 2016. Late-Breaker Abstract #2709.
Brezinski EA, Dhillon JS, Armstrong AW. Economic Burden of Psoriasis in the United States: A Systematic Review. JAMA Dermatol. 2015 Jan 7. doi: 10.1001/jamadermatol.2014.3593.
Bushnell D, Martin M, McCarrier K, et al. Validation of the Psoriasis Symptom Inventory (PSI), a patient-reported outcome measure to assess psoriasis symptom severity. J Dermatolog Treat 2013;24:356-60.
Cather J, Young M, Bergman M. Psoriasis and psoriatic arthritis. J Clin Aesthet Dermatol. 2017;10(3):S16-S25.
Chan SA, Hussain F, et al. Factors affecting adherence to treatment of psoriasis: comparing biologic therapy to other modalities. J Dermatolog Treat. 2013;24:64-9.
Choi J, Koo,J. Quality of life issues in psoriasis. J Amer Acad of Dermatology 2003;49(2)Suppl:57-61.
Coimbra S, Figueiredo A, Santos-Silva A. Brodalumab: an evidence-based review of its potential in the treatment of moderate-to-severe psoriasis. Core Evid 2014;9:89-97.
Coumbe AG, Pritzker MR, Duprez DA. Cardiovascular risk and psoriasis: beyond the traditional risk factors. CAm J Med 2014;127:12-8.
Crow JM. Psoriasis uncovered. Nature. 2012 Dec 20;492(7429):S50-1.
Croxtall JD. Ustekinumab: a review of its use in the management of moderate to severe plaque psoriasis. Drugs. 2011;71(13):1733–1753.
Daudén E, Castañeda S, Suárez C, et al.; on behalf of the Working Group on Comorbidity in Psoriasis. Clinical practice guideline for an integrated approach to comorbidity in patients with psoriasis.J Eur Acad Dermatol Venereol. 2013;27:1387-404.
Devaux S, Castela A, Archier E et al. Adherence to topical treatment in psoriasis: a systematic literature review. J Eur Acad Dermatol Venereol 2012; 26:61–7.
Gordon K, Blauvelt A, Langley R, et al. Ixekizumab for Treatment of Moderate‐to‐Severe Plaque Psoriasis: 60‐week Results from a Double‐Blind Phase 3 Induction and Randomized Withdrawal Study (UNCOVER‐1). American Academy of Dermatology Annual Meeting, San Francisco, CA; March 20–24, 2015 Poster F010.
Grozdev I, Kast D, Cao K, et al. Physical and Mental Impact of Psoriasis Severity as Measured by the Compact Short Form-12 Health Survey (SF-12) Quality of Life Tool. J Invest Dermatol. 2012;132: 1111–1116.
Griffiths CE, Reich K, Lebwohl M, et al. UNCOVER-2; UNCOVER-3 investigators. Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials. Lancet. 2015:386:541-551.
Griffiths CE, Strober BE, van de Kerkhof P, et al. Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N Engl J Med. 2010;362(2):118–128.
Guenther L, Cathers J, Lebwohl M, et al. Impact of ixekizumab treatment on sexual function in moderate-to-severe psoriasis patients: 12 week results from two Phase 3 trials UNCOVER-2 and UNCOVER-3. American Academy of Dermatology Annual Meeting, Washington, DC; March 4-8, 2016. Abstract #2712.
Gupta MA, Gupta AK, Watteel GN. Perceived deprivation of social touch in psoriasis associated with greater psychologic morbidity: an index of the stigma experience in dermatologic disorders. Cutis 1998; 61:339–342.
Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123–1132.
Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY: Translating the science of quality of life into practice: What do dermatology life quality index scores mean? J Invest Dermatol 2005;125:659–664.
Herrinton LJ, Liu L, Weng X, Lewis JD, Hutfless S, Allison JE. Role of thiopurine and anti-TNF therapy in lymphoma in inflammatory bowel disease. Am J Gastroenterol. 2011;106:2146-53.
Janowski K, Steuden S, Bogaczewicz J. Clinical and psychological characteristics of patients with psoriasis reporting various frequencies of pruritus. Int J Dermatol. 2014 Jul;53(7):820-9.
Johnson-Huang LM, Lowes MA, Krueger JG. Putting together the psoriasis puzzle: an update on developing targeted therapies. Dis Model Mech. 2012 Jul;5(4):423-33.
Kikly K, Liu, Na S, Sedgwick J. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr. Opin. Immunol. 2006;18:670-675.
Kimball AB, Gladman D, Gelfand JM, et al. National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening. J Am Acad Dermatol. 2008;58(6):1031–1042.
Kimball AB, Jacobson C, Weiss S, Vreeland MG, Wu Y: The psychosocial burden of psoriasis. Am J Clin Dermatol 2005;6:383–392.
Kimball A, Luger T, Gottlieb A, et al. Treatment with ixekizumab over 60 weeks also provided sustained improvements in itch and other patient reported outcomes Results from UNCOVER-1, a Phase 3 Trial. American Academy of Dermatology Annual Meeting, Washington, DC; March 4-8, 2016. Abstract #2501
Krueger GG, Langley RG, Finlay AY, et al. A: Patient-reported outcomes of psoriasis improvement with etanercept therapy: results of a randomized phase III trial. Br J Dermatol 2005;153:1192–1199.
Kurizky PS, Mota LM. Sexual dysfunction in patients with psoriasis and psoriatic arthritis–a systematic review. Rev Bras Reumatol. 2012;52(6):943-8.
Langley RG, Elewski BE, Lebwohl M, et al.; ERASURE Study Group; FIXTURE Study Group. Secukinumab in plaque psoriasis–results of two phase 3 trials. N Engl J Med. 2014;371(4):326-38.
Langley R, Burge R, Feldman S, et al. Treatment with ixekizumab over 60 weeks provides sustained improvements in health-related quality of life: Results from UNCOVER-1, a randomized Phase 3 trial. American Academy of Dermatology Annual Meeting, Washington, DC; March 4-8, 2016. Abstract #2710.
Lebwohl M, Papp K, Han C, Schenkel B, Yeilding N, Wang Y, Krueger GG: Ustekinumab improves health-related quality of life in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trial. Br J Dermatol 2010, 162:137–146.
Lebwohl M, Strober B, Menter A, et al. Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis.N Engl J Med. 2015;373(14):1318-28.
Leonardi CL, Kimball AB, Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet. 2008;371:1665–1674.
Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med. 2012;366(13):1190–1199.
Leonardi C, et al. Rapid Onset of Efficacy in Patients with Psoriasis Treated with Ixekizumab: A Pooled Analysis of Data from Two Phase 3 Randomized Clinical Trials (UNCOVER-2 and UNCOVER-3). American Academy of Dermatology Annual Meeting, Washington, DC; March 4-8, 2016. Abstract #3100.
Mahajan R, Handa S. Pathophysiology of psoriasis. Indian J Dermatol Venereol Leprol 2013;79:S1-9.
Mansouri B, Patel M, Menter A. Biological therapies for psoriasis. Expert Opin Biol Ther 2013;13:1715-30.
Mariette X, Tubach F, Bagheri H, et al.Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry. Ann Rheum Dis. 2010; 69: 400-8.
McDonough E, Ayearst R, Eder L, Chandran V, et al. Depression and anxiety in psoriatic disease: prevalence and associated factors. J Rheumatol. 2014;41(5):887-96.
McInnes IB, Mease PJ, Kirkham B, et al. Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2015;386(9999):1137-46.
Mrowietz U, Chouela EN, et al. Pruritus and quality of life in moderate-to-severe plaque psoriasis: post hoc explorative analysis from the PRISTINE study. J Eur Acad Dermatol Venereol. 2015 Jun;29(6):1114-20.
Menter A, Gottlieb A, Feldman S, et al.. Guidelines of care for the management of psoriasis and psoriatic arthritis Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 2008;58:826-50.
Molina-Leyva A, Jiménez-Moleón JJ. Sexual dysfunction in psoriasis: a systematic review. J Eur Acad Dermatol Venereol. 2015 Apr;29(4):649-55.
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Nestle, F. O., Kaplan, D. H. and Barker, J. Psoriasis. N. Engl. J. Med. 2009. 361, 496-509.
Papp K, Ball S, Blauvelt A, et al. Efficacy of ixekizumab therapy: Integrated analysis of 3 double-blind, controlled trials. American Academy of Dermatology Annual Meeting, Washington, DC; March 4-8, 2016. Abstract #3031.
Papp K, Cather J, Rosoph L, Sofen H, Langley RG, Matheson RT, Hu A, Day RM: The efficacy of apremilast, a phosphodiesterase-4 inhibitor, in the treatment of moderate to severe psoriasis: results of a phase 2 randomised study. Lancet 2012, 380:738–746.
Papp KA, Krueger JG, Feldman SR, et al. Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: Long-term efficacy and safety results from 2 randomized phase-III studies and 1 open-label long-term extension study. J Am Acad Dermatol. 2016 Feb 18. pii: S0190-9622(16)00026-8. doi: 10.1016/j.jaad.2016.01.013.
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Papp K, Poulin Y, Vieira A. Examining the risk of cardiovascular disease in patients with psoriasis: a critical review. Cutan Med Surg. 2013;17(2):89-105.
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Ravindran V, Scott DL, Choy EH: A systematic review and meta-analysis of efficacy and toxicity of disease modifying anti-rheumatic drugs and biological agents for psoriatic arthritis. Ann Rheum Dis 2008, 67:855–859.
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Takeshita J, Grewal S, Langan S, et al. Psoriasis and comorbid diseases: Implications for management. J Am Acad Dermatol. 2017;76(3):393-403.
Takeshita J, Mohler ER, Krishnamoorthy P, et al. Endothelial cell-, platelet-, and monocyte/macrophage-derived microparticles are elevated in psoriasis beyond cardiometabolic risk factors. J Am Heart Assoc. 2014 Feb 28;3(1):e000507.
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